Primary Job Title CEO and Founder Primary Organization PhenoVista Biosciences
Location San Diego, California, United States Regions Greater San Diego Area, West Coast, Western US Gender Male
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Mike has been a familiar and active member of the High Content Screening community since its inception. He has focused on fluorescence imaging technologies for cell biology research and phenotypic drug discovery throughout his career.
He used imaging technology extensively in his doctoral work at UC Berkeley and post doctoral research at Stanford
University working with the first fluorescent live cell physiology indicators (BCECF and FURA-2) and green fluorescent proteins. At Stanford he studied T and B cell behavior imaging T-cell activation, and examining the kinetics of cell signaling and protein redistribution on the cell surface. During this time he pioneered high-speed, 3D multiplexed imaging techniques to map GFP-tagged protein re-distribution during T-Cell activation. This launched a industrial career in imaging technology development for drug discovery.
As commercial imaging technology developer at Molecular Devices, Mike helped to lead the pioneering teams that created the first Universal Imaging Discovery-1 and the ImageXpress line of HCS imaging platforms. As an end-user, he assembled and ran a screening department that leveraged HCS extensively at Hyseq Pharmaceuticals during the race to sequence the human genome and to functionalize novel genes and discover therapeutics.
